The Aye Lab (established: July 2012) – Team Results

15 Corresponding-Author Independent Publications since 2013

-- From the American Chemical Society Journals: 
ACS Chemical Biology (2016, 2017), Biochemistry (2013, 2017), Chemical Research in Toxicology (2016), Journal of the American Chemical Society [2013, 2015 (×2), 2016]; 

-- From the Nature Publishing Group: 
Nature Chemical Biology (2017), Nature Protocols (2016), Oncogene (2015);

-- From the Cell Press:
Cell Chemical Biology [2017 (×2)]; 

-- From the ChemPubSoc Europe (Wiley-VCH): 
ChemBioChem-European Journal of Chemical Biology (2014)

Under Review/In Revision

19) May 2017Original Research (nucleotide signaling program)

Yuan Fu#, Marcus J. C. Long# et al., and Yimon Aye*

(#, co-first authors. *, corresponding author)

In Revision

18 May 2017  Original Research (electrophile signaling program in zebrafish)

Marcus J. C. Long#, Saba Parvez, Jesse R. Poganik, Brian Miller, Joseph R. Fetcho, and Yimon Aye*

(#, first author. *, corresponding author)

In Revision

17 September 2017  Original Research (electrophile signaling program in zebrafish)

Saba Parvez#, Marcus J. C. Long#, Hong-Yu Lin, Yi Zhao, Xuyu Liu, and Yimon Aye*

(#, co-first authors. *, corresponding author)

Submitted

16July 2017  Original Research (electrophile signaling program in cultured cells and in zebrafish)

Yi Zhao#, Marcus J. C. Long#, Yiran Wang, and Yimon Aye*

(#, co-first authors. *, corresponding author)

Under Peer Review

 

Published

15) September 2017 – Original Research Communication –

We are honored to contribute this manuscript to be a part of “Future of Biochemistry” Special Issue of ACS Biochemistry (scheduled for January 2018)

Precision electrophile tagging in C. elegans” (electrophile signaling program in worms)

 

Selected to be featured as an “ACS Editors” Choice” communication (open access publication)!

Click Here For LiveSlides Of The Paper

Marcus J. C. Long#, Daniel A. Urul#, Shivansh Chawla#, Hong-Yu Lin+, Yi Zhao+, Joseph A. Haegele, Yiran Wang, and Yimon Aye*

(#, co-first authors. +, co-second authors. *, corresponding author)

 

 

14) July 22 2017  Cell Chemical Biology (Original research) (electrophile signaling program)

β-TrCP1 is a vacillatory regulator of Wnt signaling

Marcus J. C. Long#, Hong-Yu Lin#, Saba Parvez, Yi Zhao, Jesse R. Poganik, Paul Huang, and Yimon Aye*

(#, co-first authors. *, corresponding author)

 Highlighted in Cornell Chronicle: Group discovers avenue for precision cancer treatment

 

13May 24 2017 Cell Chemical Biology (Perspective) (electrophile signaling program in cells and fish)

Privileged electrophile sensors: a resource for covalent drug development

Marcus J. C. Long#, and Yimon Aye*

(#, first author. *, corresponding author)

 

12) March 2017 Nature Chemical Biology (Original Research) (electrophile signaling program in cultured cells and in zebrafish)

Akt3 is a privileged first responder in isozyme-specific electrophile response


graphical-abstract_nchemb-bc160503840_2016nov18

Marcus J. C. Long#, Saba Parvez#, Yi Zhao, Sanjna L. Surya, Yiran Wang, Sheng Zhang, and Yimon Aye*

(#, co-first authors. *, corresponding author)

Highlighted in Nature Chemical Biology “News & Views”

2017 13(3):244-245

 

 

Highlighted in Cornell Chronicle: Group uses its own ‘toolset’ to probe chemical responses

 

 

11) January 2017 ACS Chemical Biology (Review Article) DOI: 10.1021/acschembio.6b01148

Subcellular Redox Targeting: Bridging In Vitro and In Vivo Chemical Biology

cb-2016-011484-r2_toc_2017jan7

Marcus J. C. Long#, Jesse R. Poganik§, Souradyuti Ghosh§, and Yimon Aye*

(#, first author. §, shared second-author. *, corresponding author)

 

10) December 2016Nature Protocols (electrophile signaling program)

“T-REX on-demand redox targeting in live cells”

nprot-2016-114-f2

Saba Parvez#, Marcus J. C. Long#,  Hong-Yu Lin†, Yi Zhao†, Joseph A. Haegele, Vanha N. Pham, Dustin K. Lee, and Yimon Aye*

(#, co-first authors. †, co-second authors. *, corresponding author)

Nature Protocols 2016 11 2328-2356


9September 2016 ACS Chem Res Toxicol (Perspective)- (electrophile signaling program)

Selected as an “ACS Editors’ Choice” Article! ec-icon-lrg

The Die is Cast: Precision electrophilic modifications contribute to cellular decision making

peer-reviewed article contributed as part of 2016 ACS CRT young investigator award to Aye Lab

slide1Marcus J. C. Long#, and Yimon Aye*

(#, first author. *, corresponding author)

Also Selected for the Journal Cover Art !

no spine minimum. half size. Editor: Maggie JEM: Diane RTP: Cynthia Porath

8) May 2016ACS Chem Bio (Original Research) (nucleotide signaling program)

Cladribine and fludarabine nucleotides induce distinct hexamers defining a common mode of reversible RNR inhibition

cb-2016-003039_0008

ACS Chemical Biology (research article) 2016 11 2021-2032

Somsinee Wisitpitthaya#, Yi Zhao, Marcus J. C. Long, Minxing Li, Elaine A. Fletcher, William A. Blessing, Robert S. Weiss, and Yimon Aye*

(#, first author.*, corresponding author)

 

7) Feb 2016 – J Am Chem Soc (Perspective) ACS OPEN ACCESS ARTICLE (electrophile signaling program)

On-demand targeting: Investigating biology with proximity-directed chemistry

Click Here For ACS LiveSlides on the journal webiste

Spotlights on Recent JACS Publications!

jacs_spotlight_logo

“Chemical Biology On Demand and In High-Definition”

Journal of the American Chemical Society (Spotlights) 2016 138 4269-4269

2016 JACS Perspective TOCJournal of the American Chemical Society (Perspective) 2016 138 3610-22

Marcus J. C. Long#,  Jesse R. Poganik, and Yimon Aye*

(#, first author. *, corresponding author)

 

6) Apr 2015J Am Chem Soc (Original Research) (electrophile signaling program)

A generalizable platform for interrogating target- and signal-specific consequences of electrophilic modifications in redox-dependent cell signaling.

Slide1

Journal of the American Chemical Society (research article) 2015 137 6232-44

Hong-Yu Lin#, Joseph A. Haegele, Michael T. Disare, Qishan Lin, and Yimon Aye*

(#, first author. *, corresponding author)

5) Jan 2015J Am Chem Soc (Original Research) (electrophile signaling program)

Substoichiometric hydroxynonenylation of a single protein recapitulates whole-cell-stimulated antioxidant response.

PreHNE Dock

Journal of the American Chemical Society (research communication) 2015 137 10-3

Saba Parvez#, Yuan Fu#, Jiayang Li, Marcus J. C. Long, Hong-Yu Lin, Dustin K. Lee, Gene S. Hu, and Yimon Aye*

(#, co-first authors. *, corresponding author)

 

4) Apr 2015 Oncogene Mini Review (nucleotide signaling program)

Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies.

RNR reviewOncogene (mini review2015  34 2011–2021
Yimon Aye*, Minxing Li#, Marcus J. C. Long and Robert S. Weiss*

(#, first author. *, co-corresponding authors)

 

3) Aug 2014ChemBioChem (Original Research) (nucleotide signaling program)

A fluorimetric readout reporting the kinetics of nucleotide-induced human ribonucleotide reductase oligomerization.ChemBioChem_2014
ChemBioChem (research article) 2014 15  2598-604

Yuan Fu, Hong-Yu Lin#, Somsinee (Sine) Wisitpitthaya#, William A. Blessing, and Yimon Aye*

(#, co-2nd authors. *, corresponding author)

 

2) Sept 2013Biochemistry (Original Research)(nucleotide signaling program)

Uncoupling of allosteric and oligomeric regulation in a functional hybrid enzyme constructed from Escherichia coli and human ribonucleotide reductase.

Slide1

Biochemistry (research article) 2013 52 7050-9

Yuan Fu#, Marcus J. C. Long, Mike Rigney, Saba Parvez, William A. Blessing, and Yimon Aye*

(#, first author. *, corresponding author)

 

1) Sept 2013J Am Chem Soc (Original Research) (electrophile signaling program)

Temporally controlled targeting of 4-hydroxynonenal to specific proteins in living cells.

overload vs T-REX

Journal of the American Chemical Society (research communication) 2013 135 14496-9

Xinqiang Fang#, Yuan Fu#, Marcus J. C. Long, Joseph A. Haegele, Eva J. Ge, Saba Parvez, and Yimon Aye*

(#, co-first authors. *, corresponding author)

 


 

Selected Previous Publications

Postdoctoral

Original research:

Mechanistic Studies of Semicarbazone Triapine Targeting Ribonucleotide Reductase in Vitro and in Mammalian Cells: Tyrosyl Radical Quenching Not Involving Reactive Oxygen Species” Yimon Aye, Marcus J. C. Long and JoAnne Stubbe; Journal of Biological Chemistry 2012 In Press.

Clofarabine Targets the Large Subunit (α) of Human Ribonucleotide Reductase in Live Cells by Assembly into Persistent Hexamers” Yimon Aye, Edward J. Brignole, Marcus J. C. Long, Johnathan Chitturulu, Catherine L. Drennan, Francisco J. Asturias, and JoAnne Stubbe; Chemistry and Biology 2012, 19, 799.

Clofarabine 5´-Di and –Triphosphates Inhibit Human Ribonucleotide Reductase by Altering the Quaternary Structure of its Large Subunit” Yimon Aye and JoAnne Stubbe; Proceedings to the National Academy of Sciences USA (Direct Submission) 2011, 108, 9815.

—–

Predoctoral

Independent review article:

“Vinyl-, Propargyl- and Allenylsilicon Reagents in Asymmetric Synthesis: Relatively Untapped Resource of Environmentally-Benign Reagents” Marcus J. Curtis-¬Long and Yimon Aye; Chemistry, A European Journal 2009, 15, 5402.

Original research:

“Structural Report for Sc[(R,R)-norephedrine-pybox](OTf)3 Dimeric Complex” Richard J. Staples and Yimon Aye; Journal of Chemical Crystallography 2008, 38, 49.

“Aluminum-catalyzed Enantio- and Diastereoselective Carbonyl Addition of Propargylsilanes. A New Approach to Enantioenriched Vinyl Epoxides” David A. Evans and Yimon Aye; Journal of the American Chemical Society 2007, 129, 9606.

“Enantioselective Scandium-catalyzed Vinylsilane Additions: A New Approach to the Synthesis of β,γ-Unsaturated α-Amino Acid Derivatives” David A. Evans and Yimon Aye; Journal of the American Chemical Society 2006, 128, 11034.

“Asymmetric, Anti–selective Scandium-catalyzed Sakurai Additions to Glyoxamide. Applications to the Syntheses of N-Boc- D-Alloisoleucine and D-Isoleucine” David A. Evans, Yimon Aye and Jimmy Wu; Organic Letters 2006, 8, 2071.

“Copper-catalyzed Asymmetric Conjugate Reduction as a Route to Novel β-Azaheterocyclic Acid Derivatives” Matthew P. Rainka, Yimon Aye and Stephen L. Buchwald; Proceedings to the National Academy of Sciences USA, 2004, 101, 5821.