Publications
The Aye Lab (established: July 2012) – Team Results
14 Corresponding-Author Publications since 2013 -- From the American Chemical Society Journals: ACS Chemical Biology (2016, 2017), Biochemistry (2013), Chemical Research in Toxicology (2016), Journal of the American Chemical Society [2013, 2015 (×2), 2016]; -- From the Nature Publishing Group: Nature Chemical Biology (2017), Nature Protocols (2016), Oncogene (2015); -- From the Cell Press: Cell Chemical Biology [2017 (×2)]; -- From the ChemPubSoc Europe (Wiley-VCH): ChemBioChem-European Journal of Chemical Biology (2014)
Under Review/In Revision/In Preparation
20) April 2017 – Original Research (electrophile signaling program in cultured cells and in zebrafish)
Yi Zhao#, Marcus J. C. Long#, Yiran Wang, and Yimon Aye*
(#, co-first authors. *, corresponding author)
– Under Review –
19) May 2017 – Original Research (nucleotide signaling program)
Yuan Fu#, Marcus J. C. Long# et al., and Yimon Aye*
(#, co-first authors. *, corresponding author)
– In Revision –
18) May 2017 – Original Research (electrophile signaling program in zebrafish)
Marcus J. C. Long#, Saba Parvez, Jesse R. Poganik, Brian Miller, Joseph R. Fetcho and Yimon Aye*
(#, first author. *, corresponding author)
– In Revision –
17) Original Research (electrophile signaling program in zebrafish)
Saba Parvez#, Marcus J. C. Long#, and Yimon Aye*
(#, co-first author. *, corresponding author)
– In Preparation –
16) Original Research (electrophile signaling program in cultured cells and in zebrafish)
Jesse R. Poganik#, and Yimon Aye*
(#, first author. *, corresponding author)
– In Preparation –
15) Original Research (electrophile signaling program in C. elegans)
Marcus J. C. Long, Souradyuti Ghosh, Joseph Haegele, et al., and Yimon Aye*
– In Preparation
Just Accepted
14) June 2 2017 – Cell Chemical Biology (Original research) (electrophile signaling program)
β-TrCP1 is a vacillatory regulator of Wnt signaling, either degrading β-catenin or preventing Nrf2 inhibition of Wnt
Marcus J. C. Long#, Hong-Yu Lin#, Saba Parvez, Yi Zhao, Jesse R. Poganik, Paul Huang, and Yimon Aye*
(#, co-first authors. *, corresponding author)
13) May 24 2017 – Cell Chemical Biology (Perspective) (electrophile signaling program in cells and fish)
Privileged electrophile sensors: a resource for covalent drug development
Marcus J. C. Long#, and Yimon Aye*
(#, first author. *, corresponding author)
Published
12) March 2017 – Nature Chemical Biology (Original Research) (electrophile signaling program in cultured cells and in zebrafish)
Akt3 is a privileged first responder in isozyme-specific electrophile response
Marcus J. C. Long#, Saba Parvez#, Yi Zhao, Sanjna L. Surya, Yiran Wang, Sheng Zhang, and Yimon Aye*
(#, co-first authors. *, corresponding author)
2017 13(3):333-338
Highlighted in Nature Chemical Biology “News & Views”
2017 13(3):244-245
11) January 2017 – ACS Chemical Biology (Review Article) DOI: 10.1021/acschembio.6b01148
Subcellular Redox Targeting: Bridging In Vitro and In Vivo Chemical Biology
Marcus J. C. Long#, Jesse R. Poganik§, Souradyuti Ghosh§, and Yimon Aye*
(#, first author. §, shared second-author. *, corresponding author)
10) December 2016 – Nature Protocols (electrophile signaling program)
“T-REX on-demand redox targeting in live cells”
Saba Parvez#, Marcus J. C. Long#, Hong-Yu Lin†, Yi Zhao†, Joseph A. Haegele, Vanha N. Pham, Dustin K. Lee, and Yimon Aye*
(#, co-first authors. †, co-second authors. *, corresponding author)
Nature Protocols 2016 11 2328-2356
9) September 2016 – ACS Chem Res Toxicol (Perspective)- (electrophile signaling program)
Selected as an “ACS Editors’ Choice” Article! 
The Die is Cast: Precision electrophilic modifications contribute to cellular decision making
– peer-reviewed article contributed as part of 2016 ACS CRT young investigator award to Aye Lab
Marcus J. C. Long#, and Yimon Aye*
(#, first author. *, corresponding author)
Also Selected for the Journal Cover Art !
8) May 2016 – ACS Chem Bio (Original Research) (nucleotide signaling program)
ACS Chemical Biology (research article) 2016 11 2021-2032
Somsinee Wisitpitthaya#, Yi Zhao, Marcus J. C. Long, Minxing Li, Elaine A. Fletcher, William A. Blessing, Robert S. Weiss, and Yimon Aye*
(#, first author.*, corresponding author)
7) Feb 2016 – J Am Chem Soc (Perspective) ACS OPEN ACCESS ARTICLE (electrophile signaling program)
On-demand targeting: Investigating biology with proximity-directed chemistry
Click Here For ACS LiveSlides on the journal webiste
Spotlights on Recent JACS Publications!
“Chemical Biology On Demand and In High-Definition”
Journal of the American Chemical Society (Spotlights) 2016 138 4269-4269
Journal of the American Chemical Society (Perspective) 2016 138 3610-22
Marcus J. C. Long#, Jesse R. Poganik, and Yimon Aye*
(#, first author. *, corresponding author)
6) Apr 2015 – J Am Chem Soc (Original Research) (electrophile signaling program)
Journal of the American Chemical Society (research article) 2015 137 6232-44
Hong-Yu Lin#, Joseph A. Haegele, Michael T. Disare, Qishan Lin, and Yimon Aye*
(#, first author. *, corresponding author)
5) Jan 2015 – J Am Chem Soc (Original Research) (electrophile signaling program)
Journal of the American Chemical Society (research communication) 2015 137 10-3
Saba Parvez#, Yuan Fu#, Jiayang Li, Marcus J. C. Long, Hong-Yu Lin, Dustin K. Lee, Gene S. Hu, and Yimon Aye*
(#, co-first authors. *, corresponding author)
4) Apr 2015 – Oncogene Mini Review (nucleotide signaling program)
Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies.
Oncogene (mini review) 2015 34 2011–2021
Yimon Aye*, Minxing Li#, Marcus J. C. Long and Robert S. Weiss*
(#, first author. *, co-corresponding authors)
3) Aug 2014 – ChemBioChem (Original Research) (nucleotide signaling program)
A fluorimetric readout reporting the kinetics of nucleotide-induced human ribonucleotide reductase oligomerization.
ChemBioChem (research article) 2014 15 2598-604
Yuan Fu, Hong-Yu Lin#, Somsinee (Sine) Wisitpitthaya#, William A. Blessing, and Yimon Aye*
(#, co-2nd authors. *, corresponding author)
2) Sept 2013 – Biochemistry (Original Research)(nucleotide signaling program)
Biochemistry (research article) 2013 52 7050-9
Yuan Fu#, Marcus J. C. Long, Mike Rigney, Saba Parvez, William A. Blessing, and Yimon Aye*
(#, first author. *, corresponding author)
1) Sept 2013 – J Am Chem Soc (Original Research) (electrophile signaling program)
Temporally controlled targeting of 4-hydroxynonenal to specific proteins in living cells.
Journal of the American Chemical Society (research communication) 2013 135 14496-9
Xinqiang Fang#, Yuan Fu#, Marcus J. C. Long, Joseph A. Haegele, Eva J. Ge, Saba Parvez, and Yimon Aye*
(#, co-first authors. *, corresponding author)
Selected Previous Publications
Postdoctoral
Original research:
Mechanistic Studies of Semicarbazone Triapine Targeting Ribonucleotide Reductase in Vitro and in Mammalian Cells: Tyrosyl Radical Quenching Not Involving Reactive Oxygen Species” Yimon Aye, Marcus J. C. Long and JoAnne Stubbe; Journal of Biological Chemistry 2012 In Press.
Clofarabine Targets the Large Subunit (α) of Human Ribonucleotide Reductase in Live Cells by Assembly into Persistent Hexamers” Yimon Aye, Edward J. Brignole, Marcus J. C. Long, Johnathan Chitturulu, Catherine L. Drennan, Francisco J. Asturias, and JoAnne Stubbe; Chemistry and Biology 2012, 19, 799.
Clofarabine 5´-Di and –Triphosphates Inhibit Human Ribonucleotide Reductase by Altering the Quaternary Structure of its Large Subunit” Yimon Aye and JoAnne Stubbe; Proceedings to the National Academy of Sciences USA (Direct Submission) 2011, 108, 9815.
—–
Predoctoral
Independent review article:
“Vinyl-, Propargyl- and Allenylsilicon Reagents in Asymmetric Synthesis: Relatively Untapped Resource of Environmentally-Benign Reagents” Marcus J. Curtis-¬Long and Yimon Aye; Chemistry, A European Journal 2009, 15, 5402.
Original research:
“Structural Report for Sc[(R,R)-norephedrine-pybox](OTf)3 Dimeric Complex” Richard J. Staples and Yimon Aye; Journal of Chemical Crystallography 2008, 38, 49.
“Aluminum-catalyzed Enantio- and Diastereoselective Carbonyl Addition of Propargylsilanes. A New Approach to Enantioenriched Vinyl Epoxides” David A. Evans and Yimon Aye; Journal of the American Chemical Society 2007, 129, 9606.
“Enantioselective Scandium-catalyzed Vinylsilane Additions: A New Approach to the Synthesis of β,γ-Unsaturated α-Amino Acid Derivatives” David A. Evans and Yimon Aye; Journal of the American Chemical Society 2006, 128, 11034.
“Asymmetric, Anti–selective Scandium-catalyzed Sakurai Additions to Glyoxamide. Applications to the Syntheses of N-Boc- D-Alloisoleucine and D-Isoleucine” David A. Evans, Yimon Aye and Jimmy Wu; Organic Letters 2006, 8, 2071.
“Copper-catalyzed Asymmetric Conjugate Reduction as a Route to Novel β-Azaheterocyclic Acid Derivatives” Matthew P. Rainka, Yimon Aye and Stephen L. Buchwald; Proceedings to the National Academy of Sciences USA, 2004, 101, 5821.