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Get the full scoop on redox signaling — accepted in Chemical Reviews!

Redox Signaling by Reactive Electrophiles and Oxidants Saba Parvez#, Marcus J. C. Long#, Jesse Poganik, and Yimon Aye* (#, co-first authors. *, corresponding author) Chemical Reviews (American Chemical Society) — just accepted The concept of cell signaling in the context… Continue Reading →

Double agent exposed in Nature Chemical Biology

The large subunit of ribonucleotide reductase—the harbinger of the DNA world—downregulates replication when inside the nucleus: it plays a tug-of-war with IRBIT/importin-α1 in the cytosol and PCNA/ZRANB3 in the nucleus Nuclear RNR-α Antagonizes Cell Proliferation by Directly Inhibiting ZRANB3 Yuan… Continue Reading →

We are very excited to welcome Bokyoung Kim to join our team at EPFL!

Bokyoung Kim has joined us as our first PhD student at EPFL! Bokyoung has just completed the Master in Chemical Biology program at the Swiss National Center of Competence in Research (NCCR) Chemical Biology, jointly run by the University of… Continue Reading →

Translocation in progress!

Following lab promotion, we are very excited to be moving to join EPFL in the near future ISIC EPFL — home of the Aye Lab Business will be uninterrupted as almost all of the team members are coming along. We… Continue Reading →

Yi et al.’s Rosetta Stone is the Hero image on ACS Central Science

Yi’s paper was selected to be featured as Hero Image of ACS Central Science   More about the contributors: Link to our previous post:            

Return of the Native? Endogenous lipid signaling electrophiles pass two of the three tests required to be classed as bona fide messengers.

Our invited contribution — a ‘problems & paradigms’ article — is now available on BioEssays (Wiley) Click here for the Video Abstract (by Jesse) Getting the message? Native reactive electrophiles pass two out of three thresholds to be bona fide… Continue Reading →

Second (February) and two (papers)! Alexandra and Yi’s double teaming paper accepted in Current Protocols in Chemical Biology

Seeing as it is the superbowl… Second (February) and two (papers)! Alexandra and Yi’s double teaming paper accepted in Current Protocols in Chemical Biology Single-protein-specific redox targeting in live mammalian cells and C. elegans Alexandra Van Hall-Beauvais#, Yi Zhao, Daniel… Continue Reading →

A new first responder has its finger on the pulse of evolutionary sensing and disease – Sanjna, Marcus, and Daniel et al’s team work just accepted to be featured in Biosensors Special Issue of ACS Chemical Biology

A new first responder has its finger on the pulse of evolutionary sensing and disease – Sanjna, Marcus, and Daniel et al’s team work on cardiovascular small heat shock protein just accepted! Cardiovascular small heat shock protein HSPB7 is a… Continue Reading →

Party like it’s 1799! A new Rosetta Stone discovered: Yi’s paper (detailing how a specific sensor translates electrophile messages to ubiquitin signaling for genome protection) welcomes 2018! —in ACS Central Science

Ube2V2 is a Rosetta Stone bridging redox and ubiquitin codes, coordinating DNA damage responses Synopsis: G-REX and T-REX double tap strategy identifies privileged electrophile responsivity of Ube2V2 to promote genome protection Yi Zhao#, Marcus J. C. Long, Yiran Wang, Sheng Zhang,… Continue Reading →

Jesse won an “impressive talk award” at the 3rd Annual Cornell Biophysics Symposium!

Jesse, our 4th year graduate student member and an AHA predoctoral fellow (and a former fellow of the Cornell NIH CBI program), was honored by an “impressive talk award” for his oral presentation at the Cornell University Annual Biophysics Symposium!… Continue Reading →

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