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Saba won a 2016 ACS Division of Biological Chemistry Travel Award

Saba Parvez, one of the graduate student founding members of the Aye lab, was selected to receive an ACS BIOL travel award to attend and present at the Fall 2016 ACS National Meeting

– we thank the ACS Division of Biological Chemistry

CU student award news

Yiran, Sanjna, Shiv, and Joe are honored by Cornell student awards

 

  • Our lab graduating senior, Yiran Wang, was honored by an ACS Cornell Section Undergraduate Research Award “to recognize accomplishments in the laboratory”. Yiran is a contributing author in two of our lab’s original research manuscripts – one just revised & resubmitted and a second in preparation. We wish Yiran all good luck with the gap-year internship and subsequent medical school training!
  • Sanjna, one of our rising juniors, won the 2016 Hill undergraduate summer research fellowship. sanjna
  • Shiv, one of our rising seniors, won the 2016 Harold Adlard Lovenberg Prize, awarded annually to a member of the junior class with a major in chemistry who has shown excellenceIMG_4759
  • Joe, one of the Aye lab graduate student founding members, was awarded a Bauer scholarship award_DSC0529

We are grateful for the support.

“T-REX On-Demand Redox Targeting” – accepted by Nature Protocols

T-REX On-Demand Redox Targeting in Live Cells

(2016) Nature Protocols In Press  (DOI: 10.1038/nprot.2016.114)

Saba Parvez#, Marcus J. C. Long#, Hong-Yu Lin+, Yi Zhao+, Joseph A. Haegele, Vanha N. Pham, Dustin K. Lee, and Yimon Aye*

#, + These authors contributed equally as joint first and second authors, respectively.

*, Correspondence author.

Credit goes to all of the present and former Aye lab T-REX team members who contributed to building of this unique toolset from the ground up.

The development of this technology is supported by the Arnold and Mabel Beckman Foundation.


“Mode of action of antileukemic drugs cladribine and fludarabine” – accepted by ACS Chemical Biology

Cladribine and Fludarabine Nucleotides Induce Distinct Hexamers Defining a Common Mode of Reversible RNR Inhibition

cb-2016-003039_0008

Somsinee Wisitpitthaya¶, Yi Zhao, Marcus J. C. Long, Minxing Li§, Elaine A. Fletcher, William A. Blessing, Robert S. Weiss§, and Yimon Aye†,‡*

 2016 May ACS Chemical Biology (original research article) ASAP 

¶,first author [Somsinee (Sine) Wisitpitthaya – see fun shot below]:

*,correspondence author

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Somsinee (Sine) Wisitpitthaya

Vanha won the Thematic Best Poster Award in Chemical Biology at the 2016 ASBMB National Meeting!

Vanha

“Chemical Biology on Demand and in High-Definition” – our recent Perspective spotlighted in J Am Chem Soc

Our open access Perspective was highlighted as a JACS spotlight

Click Here for the ACS LiveSlides

2016 JACS Perspective TOCTo understand how chemical processes in the cell produce biological responses, researchers must think small, that is, they must clarify molecular interactions that take place over minute scales of space and time. In this Perspective, Yimon Aye and colleagues survey diverse efforts to use small-molecule tools to accomplish this goal in a field known as proximity enhancement (DOI:10.1021/jacs.5b12608). They also help researchers choose among the many tools at their disposal. The authors describe two main strategies for proximity enhancement and illustrate them with many examples. In the first, more established approach, called multifunctional scaffolding, chemists devise molecules that are permanently tethered to one another; these probes elicit cellular responses by interacting with proteins of interest. In a more cutting-edge strategy known as on-demand precision targeting, researchers deploy probes containing a moiety that selectively interacts with proteins and a “latent warhead” portion that is activated on demand. The authors advise using multifunctional scaffolding for controlling or reporting biological functions based on known associations, and on-demand precision targeting for discovering new interactions and specific biological responses. They also describe innovative uses of these tools, for example how proximity targeting has helped determine the function of myriad proteins in nuclear pore complexes

Deirdre Lockwood, Ph.D.

Daniel won an NSF GRFP fellowship – we thank the National Science Foundation for the support

IMG_4792

We are honored by the 2016 ACS CRT Young Investigator Award

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