Welcome to the Aye Lab



Party like it’s 1799! A new Rosetta Stone discovered: Yi’s paper (detailing how a specific sensor translates electrophile messages to ubiquitin signaling for genome protection) welcomes 2018! —in ACS Central Science

Ube2V2 is a Rosetta Stone bridging redox and ubiquitin codes, coordinating DDR responses Synopsis: G-REX and T-REX double tap strategy identifies privileged electrophile responsivity of Ube2V2 to promote genome protection Yi Zhao#, Marcus J. C. Long, Yiran Wang, Sheng Zhang, and… Continue Reading →

We are excited to welcome Xiaopeng, Chester, Lingxi, Andreas, and Nick as the newest members of the Aye Team!

A big welcome to: our new postdoctoral researcher, Xiaopeng; our new first-year graduate students, Chester and Lingxi; and our latest recruits, Andreas and Nick, who have joined our team of undergrad researchers!

Jesse won an “impressive talk award” at the 3rd Annual Cornell Biophysics Symposium!

Jesse, our 4th year graduate student member and an AHA predoctoral fellow (and a former fellow of the Cornell NIH CBI program), was honored by an “impressive talk award” for his oral presentation at the Cornell University Annual Biophysics Symposium!… Continue Reading →

Daniel’s LiveSlides are now available for our ACS-Editors’-Choice communication

ACS Editors’ Choice Communication LiveSlides Daniel, a co-lead author of the publication, is our 3rd year graduate student and NSF GRFP fellow   Precision Electrophile Tagging in Caenorhabditis elegans Marcus J. C. Long#, Daniel A. Urul#, Shivansh Chawla#, Hong-Yu Lin+,… Continue Reading →

Glow-worms! A new protocol to perform targeted RES delivery in living worms is released

September 2017 – Original Research Communication – We are honored to contribute this manuscript to be a part of “Future of Biochemistry” Special Issue of ACS Biochemistry (scheduled for January 2018) “Precision electrophile tagging in C. elegans” The paper was selected… Continue Reading →

Our lab was honored by the 2017 ACS Buck-Whitney Award – we thank the American Chemical Society for this recognition

This biannual award selected by the Eastern New York Section of the American Chemical Society recognizes excellent and original contributions to pure & applied chemistry Link to Previous Awardees Cornell University College of Arts & Sciences News

Jesse wins a prestigious predoctoral fellowship from the American Heart Association – we thank the AHA for this honor

Jesse’s scientific contributions thus far: Just Accepted: 2017 Cell Chemical Biology β-TrCP1 is a vacillatory regulator of Wnt signaling, either degrading β-catenin or preventing Nrf2 inhibition of Wnt Published: 2017 ACS Chemical Biology Subcellular Redox Targeting: Bridging in Vitro and… Continue Reading →

Seeing Double? Two of our manuscripts just accepted by Cell Chemical Biology

Group discovers avenue for precision cancer treatment β-TrCP1 is a vacillatory regulator of Wnt signaling Marcus J. C. Long#, Hong-Yu Lin#, Saba Parvez, Yi Zhao, Jesse R. Poganik, Paul Huang, and Yimon Aye* (Original Research, #, co-first authors) eTOC: Upregulation… Continue Reading →

Our lab wins a 2017 Pershing Square Sohn Prize – we thank the PSSCRA for this highly-competitive award

  Six New York City Scientists Win Pershing Square Sohn Prize for Young Investigators in Cancer Research Aye awarded young investigator cancer research prize 2017 PSSCRA Awardees  

Lining and Paul win Douglas and Morris undergraduate summer research fellowships, respectively

  Lining Zheng and Paul Huang are two of our lab’s undergraduate researchers and junior Chemistry majors at Cornell University College of Arts & Sciences

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