The large subunit of ribonucleotide reductase—the harbinger of the DNA world—downregulates replication when inside the nucleus: it plays a tug-of-war with IRBIT/importin-α1 in the cytosol and PCNA/ZRANB3 in the nucleus

Nuclear RNR-α Antagonizes Cell Proliferation by Directly Inhibiting ZRANB3

Yuan Fu#, Marcus J. C. Long#, Somsinee Wisitpitthaya, Huma Inayet, Timothy M. Pierpont, Islam M. Elsaid, Jordanna C. Bloom, Joaquin Ortega, Robert S. Weiss, and Yimon Aye*

(#, co-first authors. *, corresponding author)

2018 Nature Chemical Biology Just Accepted

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We thank all of the contributing team members, and our collaborators, Professors Joaquin Ortega (McGill University, Canada) and Bob Weiss (Cornell Vet College, USA).