2017 January 9: ACS Chemical Biology DOI: 10.1021/acschembio.6b01148

Contributing authors: Marcus, Jesse, and Soura

Correspondence author: Yimon

Subcellular Redox Targeting:

Bridging In Vitro and In Vivo Chemical Biology

 

cb-2016-011484-r2_toc_2017jan7

Networks of redox sensor proteins within discrete microdomains regulate the flow of redox signaling. Yet, the inherent reactivity of redox signals complicates the study of specific redox events and pathways by traditional methods. Herein, we review designer chemistries capable of measuring flux and/or mimicking subcellular redox signaling at the cellular and organismal level. Such efforts have begun to decipher the logic underlying organelle-, site-, and target-specific redox signaling in vitro and in vivo. These data highlight chemical biology as a perfect gateway to interrogate how Nature choreographs subcellular redox chemistry to drive precision redox biology.