Welcome to the laboratory of electrophile and genome organization (LEAGO). Our business is understanding cellular communication processes. We are most well-known for our studies into electrophile signalling, but we also study nucleotide signalling pathways. Our work is slowly bringing both eclectic forms of cellular communication into focus. Critically, we have proven that electrophile signalling impinges on all aspects of cellular processes, and we have uncovered hidden aspects of nucleotide signalling pathways that serve to guard the genome.

We pioneered the use of photocaged electrophiles (REX technologies) to bypass many of the problems associated with the use of reactive electrophiles in cells/whole organisms. These technologies that can trigger protein specific electrophile-mediated signalling or can profile the best electrophile sensors are proving to be uniquely useful. We have also used biochemistry/cell biology/genetics to uncover novel roles of one of the most ancient enzymes, ribonucleotide reductase. Unsurprisingly, we are a multidisciplinary lab that uses chemistry, biochemistry, cell biology, genetics and a number of model organisms to solve complex problems. Our work is of significant relevance to human health. Through our united team effort, we strive to develop novel interventions and to better understanding of current drugs through active collaborations with industrial scientists.

 

Targetable Reactive Electrophiles and Oxidants (T-REX)


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A Representative T-REX Photocaged Electrophile Covalently Bound to HaloTag


 

RNR Flashmob Unveiled by Stopped-Flow Fluorescence Method

RNR Flashmob Unveiled by Stopped-Flow Fluorescence Method